COVID Vaccine Injury Science Overview
Covid Vaccine Injury Emerging Research
Long Covid/Long Vax
Vaccines (2024) - Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS) blood markers for covid vaccine injury https://doi.org/10.3390/vaccines12070790
Vaccines (2023) - Chronic Fatigue and Dysautonomia following COVID-19 Vaccination Is Distinguished from Normal Vaccination Response by Altered Blood Markers https://doi.org/10.3390/vaccines11111642
"In PACVS, serological vaccination–response appeared significantly altered, allowing discrimination from normal post-vaccination state by increased Angiotensin II type 1 receptor antibodies, decreased alpha-2B adrenergic receptor antibodies and increased IL-6."
Frontiers in Immunology (2024) - High serum prevalence of autoreactive IgG antibodies against peripheral nerve structures in patients with neurological post-COVID-19 vaccination syndrome https://doi.org/10.3389/fimmu.2024.1404800
"High serum prevalence of autoreactive IgG antibodies against peripheral nerve structures in patients with neurological post-COVID-19 vaccination syndrome"
It essentially shows Long Vax sufferers have higher levels of autoreactive antibodies against peripheral nerve structures.
Journal of Neurology (2023) - Neurological symptoms after COVID-19 vaccination: a report on the clinical presentation of the first 50 patients https://doi.org/10.1007/s00415-023-11895-9
"The median latency between receiving the vaccination and onset of symptoms was three days, ranging from one hour to 30 days. A SARS-CoV-2 infection occurred in 16 patients (32%) after their vaccination and onset of reported symptoms. All 16 had a mild course, but 10 (63%) reported an exacerbation of pre-existing symptoms."
Spike Biodistribution Study
In 2021, a biodistribution study was leaked from Japan. https://pandemictimeline.com/wp-content/uploads/2021/08/Pfizer-bio-distribution-confidential-document-translated-to-english.pdf
Pfizer commissioned a Japanese researcher to do a biodistribution study to inject the mRNA vaccine into rats to learn where the nano-lipid particles in the vaccine could potentially travel to after injection. Not only did they discover the lipid nano-particles did NOT stay in the arm, but rather, it travelled everywhere in the body. The kidneys, lungs, brain, and reproductive organs. Pfizer failed to tell the world. The scientists leaked the report anyway.
Nature (2025) - Spike biodistribution study further describing the findings of the Japanese team. https://doi.org/10.1038/s41587-024-02528-1
These researchers also identified off-target protein accumulation in heart tissue, and changes in the expression of immune and vascular proteins.
Spike Clearance/Persistence
Persistent Spike -
Frontiers in Immunology (2022) - A study looking into the persistence of the SARS CoV-2 spike protein in vaccinated individuals. Researchers found people with self-reported vaccine injury have "mutant spike." It's not the same as wild spike. https://pubmed.ncbi.nlm.nih.gov/35082777/
Neurotoxicity
In 2022, React19 did a scientific lit review to understand "The Spike Protein Problem" https://www.react19.org/science-and-research/lit-reviews-and-surveys/react19-research-the-spike-protein-problem
Lit reviews show that the spike is neurotoxic, and can cause some life-altering neurologic complications. Several patient-driven case reports on Neuropathy and autoimmunity can be found in the published literature:
SARS-CoV-2 vaccination complicated by small fiber neuropathy, mast cell activation syndrome, and pericarditis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681913/
Small Fiber Neuropathy Triggered by COVID-19 Vaccination: Association with FGFR3 Autoantibodies and Improvement during Intravenous Immunoglobulin Treatment: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9891845/
Frameshifting
Nature (2023) - N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting https://www.nature.com/articles/s41586-023-06800-3
A group of scientists tested the translation of the N1-methylpseudouridine in the mrna and found that 1 in 9 times that the mRNA is transcribed, a rogue protein is created. So essentially what they found was that the code to create the spike protein is translated incorrectly every 1 out of 9 times. An mRNA covid vaccine typically will do literally trillions of translations from a single injection to drive the body to create a spike protein. One in nine times this occurs incorrectly, resulting in an unknown protein with unknown effects on the body and the immune response.
Potential problems are auto-immunity, antibodies that attack tissues and other proteins that attack the human body and that’s just the beginning. The researchers submitted to the journal early in 2023, Nature delayed the publication for more than a year for unknown reasons.
Cardiovascular
European Journal of Heart Failure (2023) - Sex-specific differences in myocardial injury incidence after COVID-19 mRNA-1273 booster vaccination https://doi.org/10.1002/ejhf.2978
Another very interesting paper, looking at blood tests of all people given a booster, and comparing it with a control group. Cardiac damage was “common.”
Vaccine (2024) - Association of SARS-CoV-2 immunoserology and vaccination status with myocardial infarction severity and outcome. https://www.sciencedirect.com/science/article/pii/S0264410X24009873
"The combination of vaccination and natural SARS-CoV2 infection was associated with the development of severe heart failure and cardiogenic shock in patients with STEMI, possibly related to an increased serological response."
Fibrinogen Microclots - CoVerse collection of studies: https://coverse.org.au/health-professionals/diagnosis/
David Putrino with Mt Sinai is also looking at microclots in the LC and LV patients they are seeing.
Nature (2024) - Fibrin drives thromboinflammation and neuropathology in COVID-19. https://www.nature.com/articles/s41586-024-07873-4
similar mechanisms after vaccination.
Nature Cardiovascular (2022) - Apparent risks of postural orthostatic tachycardia syndrome diagnoses after COVID-19 vaccination and SARS-Cov-2 Infection https://www.nature.com/articles/s44161-022-00177-8
Large analysis on POTS in medical records timed with Covid vaccination.
Genetic Integration
There’s also the problem of genetic integration. NOBODY is checking this.
Here’s a paper from the beginning of 2022(!!!!) with an in vitro experiment showing it’s possible: https://doi.org/10.3390/cimb44030073
DNA contamination issues which, combined with the above paper, suggests a very dangerous possibility, https://doi.org/10.31219/osf.io/mjc97
React 19 Research
Post COVID-19 vaccination syndrome (PCVS) is a complex chronic illness that presents with a broad range of persistent symptoms including systemic, neurologic, cardiac, and immunological. Few studies have investigated this population in detail so relatively little is known about symptom prevalence and severity, expected clinical evolution, impact on daily functioning, potential risk factors, recovery, and relative similarities and differences with other complex chronic illnesses.
Study Outline
Post COVID-10 vaccination syndrome - Symptoms, Tests, Diagnoses, Treatments.
-7000 enrolled. 1250 respondents completed.
We estimated the prevalence, severity, and time evolution of 137 symptoms across many organ systems. We measured the impact on health, daily functioning, pre/post COVID infections, and preexisting conditions. The study also investigates what tests, diagnoses, and treatments have been tried and their perceived effect.
Authors: Edoardo Galli PhD, Danice Hertz MD , Linda Simoni-Wastila PhD
-
Symptom Severity
Pain/discomfort maps show clusters of paresthesia type of pain towards the extremities.
- PCVS shares many symptoms with Long Covid and other complex chronic illnesses. Fatigue, Brain-fog, and Exercise Intolerance/PEM are the most prevalent symptoms.
More prevalent in PCVS than Long Covid
- Paresthesia
- Auditory symptoms
Less prevalent in PCVS than Long Covid
- Respiratory symptoms
- Taste/smell symptoms
-
Symptoms Over Time
For ~70% of people symptoms started within 1st week.
• PCVS respondents seem to have more symptoms than Long Covid.
• Similarly to Long Covid, almost everyone still experiences symptoms.
-
Demographics
Most PCVS respondents were women (68.8%) and between the ages of 35 and 64 (68.4%). This trend is consistent with what observed in other similar complex chronic illnesses.
NIH Research

Avindra Nath or Avi Nath, MD, is a physician-scientist who specializes in neuroimmunology. Dr. Nath serves as the intramural clinical director of the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health (NIH) in the U.S. and chief of the Section of Infections of the Nervous System at NINDS. He is the principal investigator of the NIH Post-Infectious ME/CFS Study and two long COVID studies including An Observational Study of Neurologic Function after COVID-19 Infection, which will focus more specifically on characterizing post-COVID neurologic sequelae, including abnormalities in brain structure, neurologic function, and autonomic nervous system function.
Dr. Nath has published four studies detailing neurologic events triggered by vaccination. In addition to characterizing these elusive conditions, his papers include the following:
- Confirms elusive neuro complications after vaccination.
- Provides guidance for diagnostic testing and possible therapeutics.
- Points out that drug company immunity provides a negative feedback loop.
NIH Studies from Dr. Avindra Nath
In May 2021 Dr Nath jumps on a paper with colleagues to discuss the importance of being cognizant of vaccinating in the environment of neurological complications.
“Concern about neurological complications from COVID‐19 vaccines escalated in the fall of 2020, when 2 patients developed transverse myelitis after receiving the Oxford/AstraZeneca vaccine. 1 One case was ultimately deemed unlikely to be related to the vaccination (the patient had pre‐existing multiple sclerosis), whereas the other was determined to be possibly related. 2 Data from the mRNA vaccine clinical trials showed that 7 cases out of 37,000 vaccine recipients developed Bell's palsy and none developed Guillain‐Barré syndrome (GBS). “
“As of March 2, 2021, 51,755,447 dosages of the vaccines have been administered in the United States and 9,442 reports of adverse reactions to the vaccines have been submitted to VAERS. The most common neurological symptoms included dizziness, headache, pain, muscle spasms, myalgia, and paresthesias, which are expected to occur as acute, transient effects of the vaccination. Rare cases of tremor, diplopia, tinnitus, dysphonia, seizures, and reactivation of herpes zoster have been reported. There are also cases of stroke (17 cases), GBS (32 cases), facial palsy (190 cases), transverse myelitis (9 cases), and acute disseminated encephalomyelitis (6 cases) in the VAERS database. However, this does not suggest a causal link with the vaccination.”
“The GBS/Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Foundation provides the following guideline: for the rare person who develops GBS within 4 to 6 weeks of receiving an immunization, it seems prudent to avoid that vaccination in the future. “
In July 2021 Dr Nath detailed vaccines in general and the neurological complications identified with previous vaccines of the past, Guillain Barre, ADEM, Transverse myelitis, encephalitis, autonomic dysfunction. He points to VAERS already identifying multiple neurological complications to covid vaccines.
"…However, the rapidity of approval, and history of prior vaccination regimens resulting in neurological and other complications, creates concern surrounding widespread vaccination. …A number of neurological complications of these vaccines are now being reported in the most comprehensive registry, the Vaccine Adverse Events Reporting System (VAERS) database. These include strokes, cranial neuropathies including Bell’s palsy, tinnitus and trigeminal neuralgia, peripheral neuropathies, dysautonomia, acute disseminated encephalomyelitis, transverse myelitis and AIDP .. however, it is too early to know the true incidence and risk factors for these complications. They are thought to be immune-mediated and early recognition and treatment with immunomodulatory therapies might be warranted…Recently, blood clots occurring 7–14 days after administration have been reported, primarily in young women on oral contraceptive medications… Following review, the recommendation and emergency use authorization for this vaccine were reaffirmed for individuals aged 18 years and older, with a warning regarding rare clotting events primarily among women aged 18–49 years.”
“Prior studies have shed light on the likelihood of neurological complications following vaccination. These data can be difficult to interpret and are often seen as controversial, suffering from potential reporting bias and lack of clear causality, but illustrate theoretical concerns for both patients and physicians and must be acknowledged.”
NIH Study on Neurological complications after Covid vaccination. Dr Danice Hertz and Brianne Dressen were participants.
This observational study suggests that a variety of neuropathic symptoms may manifest after SARS-CoV-2 vaccinations and in some patients might be an immune-mediated process
Immunotherapy and early intervention with the same appears to be key in treating this syndrome.
studied 23 patients (92% female; median age 40years) reporting new neuropathic symptoms beginning within 1 month after SARS-CoV-2 vaccination. 100% reported sensory symptoms comprising severe face and/or limb paresthesias, and 61% had orthostasis, heat intolerance and palpitations. Autonomic testing in 12 identified seven with reduced distal sweat production and six with positional orthostatic tachycardia syndrome. Among 16 with lower-leg skin biopsies, 31% had diagnostic/subthreshold epidermal neurite densities ( 5%), 13% were borderline (5.01-10%) and 19% showed abnormal axonal swelling. Biopsies from randomly selected five patients that were evaluated for immune complexes showed deposition of complement C4d in endothelial cells. Electrodiagnostic test results were normal in 94% (16/17). Together, 52% (12/23) of patients had objective evidence of small-fiber peripheral neuropathy.
Complement system issues, involving the endothelial cells, the enothelium, blood vessel material.
Objective Findings:
Autonomic
7 out of 12 had reduced distal sweat production
6 out of 12 had Positional Othostatic Tachycardia Syndrome (POTS)
Small Fiber Neuropathy
of 16 lower leg biopsies:
31% had diagnostic/subthreshhold epidermal neuritis.
13% were borderline
19% showed abnormal axonal swelling
Electrodiagnosic
test results were normal in 94%
Imaging
100% of MRIs were normal
Small fiber neuropathy in young healthy women. The typical onset is from diabetes, or in males aged 59.
"All our patients had neuropathic symptoms but objective findings of SFN were present in a few patients only."
"Anti-spike protein immune responses may link post-Covid and post-vaccine syndromes."
"In studies of mouse sensory ganglia, small-fiber neurons preferentially display the ACE-2 docking protein for SARS-COV- consistent with a potential predominance of SFN." Once again, the neurotoxic spike protein comes into play. An auto-immunity as a secondary response then causing SFN?
in October 2023 Nath wrote an editorial in the prestigious journal Neurology. “Neurologic Complications With Vaccines: What We Know, What We Don't, and What We Should Do”
A Short Summary:
“Despite such measures, vaccines are not without side effects including those that impact the nervous system. Numerous case reports and case series point to these possibilities… Action is needed that brings together manufactures, health care agencies, clinical and bench scientists and legislatures on a global platform to investigate vaccine related neurological adverse events and develop ways to prevent and treat them.”